Delayed inflammatory mRNA and protein expression after spinal cord injury
نویسندگان
چکیده
منابع مشابه
Increased expression of spinal cord Fos protein induced by bladder stimulation after spinal cord injury.
These studies examined Fos protein expression in spinal cord neurons synaptically activated by stimulation of bladder afferent pathways after spinal cord injury (SCI). In urethan-anesthetized Wistar rats after SCI for 6 wk, intravesical saline distension significantly (P </= 0.005) increased the number of Fos-immunoreactive (IR) cells in the rostrolumbar (L1, 38 cells/section; L2, 29 cells/sect...
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spinal cord injury (sci) results in up regulation and/or down regulation of several genes that may affect neuronal death and subsequent loss of motor function and also neuropathic pain. to expand a practical therapy, it is essential to recognize the specific molecular pathways altered as a function of time after spinal cord injury. this will help to develop strategies for positive manipulation ...
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Spinal cord injury (SCI) actuate to complex cellular and molecular interactions within the central nervous system in a heave to repair the initial tissue damage. The pathophysiology of acute spinal cord injury (SCI) involves primary and secondary mechanisms. Neuroinflammation is an important secondary injury process in SCI. The local inflammatory microenvironment within the injured spinal cord ...
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We provide the first data that cathepsin B (Cath B), a lysosomal cysteine protease, is up-regulated following contusion-spinal cord injury (SCI). Following T12 laminectomy and moderate contusion, Cath B mRNA and protein expression profiles were examined from 2 to 168 h post-injury in rats using real-time PCR and immunoblots, respectively. Contusion injury significantly increased [mRNA]Cath B in...
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ژورنال
عنوان ژورنال: Journal of Neuroinflammation
سال: 2011
ISSN: 1742-2094
DOI: 10.1186/1742-2094-8-130